The Next Pandemic: SARS-CoV-2/COVID-19

[Buffalo_Gal]

Just now, B-Man said:

 

 

TYLER O’NEIL COVERS President Trump’s Chinese Coronavirus Press Conference.

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What? My Cliff notes aren't good enough for you? ?

 

[sabrecrazed]

4 minutes ago, Buffalo_Gal said:

What? My Cliff notes aren't good enough for you? ?

 

I appreciate them and look forward to them daily. I'm at work and can't see them. 

[Taro T]

3 hours ago, Scraps said:

 

Isn't the "WHO" test available to any country that asks for it?  Is it incumbent on the WHO of offer it?  Other countries went directly to the German company.

 

It seems that CDC is to restrictive.  They developed a botched test and It seems as though corporations that work in the field of medical testing were not allowed to develop tests until it was too late.  At the very least, once problems were noted in the CDC test, they probably should have obtained some of the German ones.

 

How does any of that make the original post you took exception to to be "almost all ... factually incorrect?"  

 

And whether the WHO offers the information on how to make the test or gets requests for that information (really don't see this level of semantics mattering and wasn't addressed in the OP either) doesn't matter as the US announced their own protocol the day the WHO (not Germany, the WHO) started pushing the German test.

 

Not this this matters relative to the OP either, but how would the CDC have the German tests (which neither it, the NIH, nor the FDA had afaik done any testing of their own on) ready for use before they could remake their own blank samples which apparently was the CDC's test kit's issue?

 

[Buffalo_Gal]

He's going on about  the Democrats delaying confirmations (100 people still waiting for confirmations). He's "warning" Congress now, and he will take it to court.

 

 

 

 

[B-Man]

6 minutes ago, Buffalo_Gal said:

What? My Cliff notes aren't good enough for you? ?

 

 

 

 

 

[Buffalo_Gal]

I thought he might sell the extra ventilators. and then he said we will sell to Russia (!!!) because Moscow will be in trouble.

Now talking about NYC adding COVID-19 people due to other reasons (like heart attacks).

Does anyone REALLY  believe numbers from some of  these countries?

 

Press: the lab in Wuhan - a person got infected, infected her boyfriend, and then went to the wet markets
Trump: well, I don't want to say

Will not discuss what he and Xi said about that laboratory. Not appropriate.

He was all for WHO at the start, and then you see all their mistakes... and how they are so pro-China>
Mentioned Pelosi's Chinatown excursion.

 

Edited April 15, 2020 by Buffalo_Gal

[Magox]

Different approach.  Very quick and forceful responses.   Is not allowing the reporters to ask follow up questions.   Moves quickly onto the next question.    Shorter time period briefers.

 

This is a better tact for him.

[Buffalo_Gal]

7 minutes ago, Magox said:

Different approach.  Very quick and forceful responses.   Is not allowing the reporters to ask follow up questions.   Moves quickly onto the next question.    Shorter time period briefers.

 

This is a better tact for him.

They asked questions. I do not think the #######s were called on, however.

 

[B-Man]

2 minutes ago, Buffalo_Gal said:

They asked questions. I do not think the #######s were called on, however.

 

 

Who ?

 

.

[Magox]

Just now, Buffalo_Gal said:

They asked questions. I do not think the #######s were called on, however.

 

 

I think he should continue doing this rapid fire form of answering questions.  Makes him look more of a presidential leader than someone getting in a tic for tac skirmish with a reporter.  
 

I thought it was a better look for him today.

 

I think he is being advised to cut the Q&A’s down in time.

[Buffalo_Gal]

Just now, B-Man said:

 

Who ?

 

.

The ridiculous gotchya press members.

 

[dubs]

I caught The Herd for a few minutes today and all they were talking about was how Covid19 was systematic racism or something like that. Anyway, went to the cdc website to check it out and according to the cdc demographic reporting information as of 4/14, there were 398,852 confirmed coronavirus cases in the US. 78% of them were reported with “race unspecified”. Only 22% had “race specified”, so 88,078.  
 

Of the cases with “race specified” 64% were reported to be white. Now, the white population in the US is around 72% as of 2016.  However, in NYC where this has been the hardest hit for obvious reasons (world gateway, density, public transport) the white population is only 42.7%. 
 

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html

 

Point being, how does Covid19 reflect racism or something?  Doesn’t make much sense. 

Edited April 15, 2020 by dubs

[Buffalo Bills Fan]

54 minutes ago, Buffalo_Gal said:

I thought he might sell the extra ventilators. and then he said we will sell to Russia (!!!) because Moscow will be in trouble.

Now talking about NYC adding COVID-19 people due to other reasons (like heart attacks).

Does anyone REALLY  believe numbers from some of  these countries?

 

Press: the lab in Wuhan - a person got infected, infected her boyfriend, and then went to the wet markets
Trump: well, I don't want to say

Will not discuss what he and Xi said about that laboratory. Not appropriate.

He was all for WHO at the start, and then you see all their mistakes... and how they are so pro-China>
Mentioned Pelosi's Chinatown excursion.

 

 

There is ACE2 receptor along with furin in heart. 

SARS-CoV-2 and ACE2

Angiotensin-converting enzyme 2 (ACE2) is a membrane-bound aminopeptidase that has a vital role in the cardiovascular and immune systems4. ACE2 is involved in heart function and the development of hypertension and diabetes mellitus. In addition, ACE2 has been identified as a functional receptor for coronaviruses4, including SARS-CoV and SARS-CoV-2. SARS-CoV-2 infection is triggered by binding of the spike protein of the virus to ACE2, which is highly expressed in the heart and lungs4. SARS-CoV-2 mainly invades alveolar epithelial cells, resulting in respiratory symptoms. These symptoms are more severe in patients with CVD, which might be associated with increased secretion of ACE2 in these patients compared with healthy individuals. ACE2 levels can be increased by the use of renin–angiotensin–aldosterone system inhibitors. Given that ACE2 is a functional receptor for SARS-CoV-2, the safety and potential effects of antihypertension therapy with ACE inhibitors or angiotensin-receptor blockers in patients with COVID-19 should be carefully considered. Whether patients with COVID-19 and hypertension who are taking an ACE inhibitor or angiotensin-receptor blocker should switch to another antihypertensive drug remains controversial, and further evidence is required.

Acute cardiac injury

Reports suggest that the Middle East respiratory syndrome-related coronavirus (MERS-CoV) can cause acute myocarditis and heart failure5. SARS-CoV-2 and MERS-CoV have similar pathogenicity, and the myocardial damage caused by infection with these viruses undoubtedly increases the difficulty and complexity of patient treatment. Myocardial injury associated with the SARS-CoV-2 occurred in 5 of the first 41 patients diagnosed with COVID-19 in Wuhan, which mainly manifested as an increase in high-sensitivity cardiac troponin I (hs-cTnI) levels (>28 pg/ml)3. In this study, four of five patients with myocardial injury were admitted to the intensive-care unit (ICU), which indicates the serious nature of the myocardial injury in patients with COVID-19. Blood-pressure levels were significantly higher in patients treated in the ICU than in those not treated in the ICU (mean systolic blood pressure 145 mmHg versus 122 mmHg; P < 0.001)3. In another report of 138 patients with COVID-19 in Wuhan, 36 patients with severe symptoms were treated in the ICU1. The levels of biomarkers of myocardial injury were significantly higher in patients treated in the ICU than in those not treated in the ICU (median creatine kinase (CK)-MB level 18 U/l versus 14 U/l, P < 0.001; hs-cTnI level 11.0 pg/ml versus 5.1 pg/ml, P = 0.004), suggesting that patients with severe symptoms often have complications involving acute myocardial injury1. In addition, among the confirmed cases of SARS-CoV-2 infection reported by the National Health Commission of China (NHC), some of the patients first went to see a doctor because of cardiovascular symptoms. The patients presented with heart palpitations and chest tightness rather than with respiratory symptoms, such as fever and cough, but were later diagnosed with COVID-19. Among the people who died from COVID-19 reported by the NHC, 11.8% of patients without underlying CVD had substantial heart damage, with elevated levels of cTnI or cardiac arrest during hospitalization. Therefore, in patients with COVID-19, the incidence of cardiovascular symptoms is high, owing to the systemic inflammatory response and immune system disorders during disease progression.

The mechanism of acute myocardial injury caused by SARS-CoV-2 infection might be related to ACE2. ACE2 is widely expressed not only in the lungs but also in the cardiovascular system and, therefore, ACE2-related signalling pathways might also have a role in heart injury. Other proposed mechanisms of myocardial injury include a cytokine storm triggered by an imbalanced response by type 1 and type 2 T helper cells3,6, and respiratory dysfunction and hypoxaemia caused by COVID-19, resulting in damage to myocardial cells.

Chronic cardiovascular damage

A 12-year follow-up survey of 25 patients who recovered from SARS-CoV infection found that 68% had hyperlipidaemia, 44% had cardiovascular system abnormalities and 60% had glucose metabolism disorders7.

 

https://www.nature.com/articles/s41569-020-0360-5?fbclid=IwAR3Ni4Y6EokoleVLOGkmHia8Si03IwBuGV8kRTJjUJEBGS5ULlfAOHb2gHE

 

It's why this is so complex understand both sides. 

 

 

I wonder President Trump when he finds out more about the lab. Hopefully shares with everyone.

 

Edited April 15, 2020 by Buffalo Bills Fan

[fansince88]

1 hour ago, Buffalo_Gal said:

What? My Cliff notes aren't good enough for you? ?

 

They are better then some "off the cliff" notes I see here. 

[GG]

34 minutes ago, dubs said:

I caught The Herd for a few minutes today and all they were talking about was how Covid19 was systematic racism or something like that. Anyway, went to the cdc website to check it out and according to the cdc demographic reporting information as of 4/14, there were 398,852 confirmed coronavirus cases in the US. 78% of them were reported with “race unspecified”. Only 22% had “race specified”, so 88,078.  
 

Of the cases with “race specified” 64% were reported to be white. Now, the white population in the US is around 72% as of 2016.  However, in NYC where this has been the hardest hit for obvious reasons (world gateway, density, public transport) the white population is only 42.7%. 
 

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html

 

Point being, how does Covid19 reflect racism or something?  Doesn’t make much sense. 

 

NYC and Illinois deaths are heavily skewed towards blacks and Hispanics.  

[SoCal Deek]

54 minutes ago, GG said:

 

NYC and Illinois deaths are heavily skewed towards blacks and Hispanics.  

And this is important why?

[meazza]

3 minutes ago, SoCal Deek said:

And this is important why?

Asians are racists.

[SoCal Deek]

Just now, meazza said:

Asians are racists.

Thanks...I always forget about those wascally Asians. They’re super sneaky!

[njbuff]

5 minutes ago, SoCal Deek said:

And this is important why?

 

The Coronavirus hates minorities.

 

?

[dpberr]

13 minutes ago, SoCal Deek said:

And this is important why?

Same in Philadelphia. The hardest hit neighborhoods are the poorest, and largely black.

 

Don't think it's so much race - the virus isn't hunting black people or Hispanics like it's some race bullet.  It's the socioeconomics. Poverty, poor health outcomes (obesity, diabetes, asthma), poor healthcare (don't have a doctor or see one regularly),  coupled with cramped living conditions, possibly living in multi-generational households which raises the risk of exposure, heavy dependence on mass transit which also  raises risk of exposure.

 

Throw in substance abuse, homelessness and inability to keep work due to previous incarceration (especially for males) and you've got a lot of potential issues.