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An agonist is a chemical that binds to some receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.

 

I thought an agonist was someone who kept posting the same crap over and over and over again.

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Has Obamunism been recognized as a disease like Alcoholism?

 

The first stage of Alcoholism is recognizing you have a problem. Most, but not all, of my Obamabot friends have woken up from their 2008 hangover and realized, yeah. We've got a problem :wallbash:

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(This is a repost from the other marijuana thread in order to consolidate the information)

 

Here are listed some of the medicinal properties of THC for those that feel it is just for stoners. This info is from the link below.

 

THC is a partial agonist at CB1 and cannabinoid receptor 2 (CB2) analogous to AEA, and underlying many of its activities as a psychoactive agent, analgesic, muscle relaxant and antispasmodic. Additionally, it is a bronchodilator, neuroprotective antioxidant, antipruritic agent in cholestatic jaundice and has 20 times the anti-inflammatory power of aspirin and twice that of hydrocortisone. THC is likely to avoid potential pitfalls of either COX-1 or COX-2 inhibition, as such activity is only noted at concentrations far above those attained therapeutically.

 

This table shows the medicinal effects of the various cannabinoids and terpenes.

 

http://www.ncbi.nlm....946/table/tbl1/

 

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

 

http://www.ncbi.nlm....les/PMC3165946/

Edited by Bob in Mich
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Old dope, new tricks: the new science of medical cannabis

26 August 2014, 9.48pm BST

 

http://theconversati...-cannabis-30828

 

This is from an Australian article

 

THC clearly has important therapeutic effects in multiple sclerosis and pain, in stimulating appetite in HIV or cancer patients, and even for anxiety disorders, such as post-traumatic stress disorder.

 

No medicine is perfect: opiates control pain but may be addictive and constipating; antidepressants lift mood but may numb you out and ruin your sex life; statins can lower your cholesterol but can cause muscle wastage. All drugs are poisons, it’s just a matter of the dose you’re taking.

 

Cannabis has its own positives and negatives, and the risks involved in its regular use, particularly during adolescence, continue to be well ventilated. But if we’re clever about our use, then it can be a most valuable therapeutic: a voyage of rediscovery is long overdue.

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Old dope, new tricks: the new science of medical cannabis

26 August 2014, 9.48pm BST

 

http://theconversati...-cannabis-30828

 

This is from an Australian article

 

THC clearly has important therapeutic effects in multiple sclerosis and pain, in stimulating appetite in HIV or cancer patients, and even for anxiety disorders, such as post-traumatic stress disorder.

 

No medicine is perfect: opiates control pain but may be addictive and constipating; antidepressants lift mood but may numb you out and ruin your sex life; statins can lower your cholesterol but can cause muscle wastage. All drugs are poisons, it’s just a matter of the dose you’re taking.

 

Cannabis has its own positives and negatives, and the risks involved in its regular use, particularly during adolescence, continue to be well ventilated. But if we’re clever about our use, then it can be a most valuable therapeutic: a voyage of rediscovery is long overdue.

 

Negatives?!? Heresy.

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Medical Marijuana Research Hits Wall of U.S. Law

 

By Serge Kovaleski AUG. 9, 2014

 

http://www.nytimes.c...l-law.html?_r=0

 

From the article

 

To obtain the drug legally, researchers like Dr. Sisley must apply to the Food and Drug Administration, the Drug Enforcement Administration and the National Institute on Drug Abuse — which, citing a 1961 treaty obligation, administers the only legal source of the drug for federally sanctioned research, at the University of Mississippi. Dr. Sisley’s proposed study also had to undergo an additional layer of review from the Public Health Service that is not required for other controlled substances in such research.

 

The process is so cumbersome that a growing number of elected state officials, medical experts and members of Congress have started calling for loosening the restrictions. In June, a letter signed by 30 members of Congress, including four Republicans, called the extra scrutiny of marijuana projects “unnecessary,” saying that research “has often been hampered by federal barriers.”

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I have a distant relative that's a heroin addict.

Can marijuana cure her of that?

 

If this is a serious question then you could start by looking into the recent research.

 

I would point out that studies sponsored by the National Institute on Drug Abuse, until very recently, were designed to show the harm of cannabis rather than its possible medical benefits. Keep that in mind when reviewing the studies.

 

Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

 

17 September 2013

 

http://www.ncbi.nlm....pubmed/23624062

 

From the research report

 

Research over the past decade has shed light on the influence of endocannabinoids (ECs) on the opioid system. Evidence from both animal and clinical studies point toward an interaction between these two systems, and suggest that targeting the EC system may provide novel interventions for managing opiate dependence and withdrawal.

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Well, no one believes some guy making claims on this board without links, right? So, I provided links to articles that I found.

 

When looking for research reports, I went to a site that I thought people would trust. I linked to reports on the US Government's 'National Institute of Health' website. http://nih.gov

 

What websites are more trustworthy for scientific research reports?

 

Have you looked at other trustworthy websites to find out whether or not these claims regarding cannabinoids are valid? Can you provide links to more current valid research reports which debunk these claims?

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Well, no one believes some guy making claims on this board without links, right? So, I provided links to articles that I found.

 

When looking for research reports, I went to a site that I thought people would trust. I linked to reports on the US Government's 'National Institute of Health' website. http://nih.gov

 

What websites are more trustworthy for scientific research reports?

 

Have you looked at other trustworthy websites to find out whether or not these claims regarding cannabinoids are valid? Can you provide links to more current valid research reports which debunk these claims?

 

Nobody actually cares. You're not posting so much as masturbating.

 

You understand that, right?

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