I live in south Buffalo so I don't have to take the 219 or anything, but if you wanted, you could take the 90, get off on the 400 at Seneca I believe (first exit), work your way up to Abott and take Abott straight down depending on what your plan is for parking.
Or like you said you could come off the skyway and take Milestrip but that gets backed up as well ( I used to take that route when I lived on the west side).