My fear is they'll rush four as usual, giving Burrow all the time he wants in the pocket waiting for one of the best WR corps in the league to get open against Poyer, White, and Taron, none of whom can cover for long anymore.
My hope is that they regularly blitz Dorian or Bishop, both of who can get home, so that Burrow has to unload quickly, and use Hairston's speed to help shut down Chase, and (no choice) take their chances with Higgins. They'll adjust, but so can the Bills, maybe with a full suite of unpredictable blitzes.
Whether they win or lose, I can see us all seeing the outcome a part of pattern we've seen all season.