The only thing I'm sure of on this is that NIMBY would be a major problem. And just like with global warming, people have brought up serious issues. Accident, terrorist attack or something else. And some people argue that nuclear power is just as bad in producing green house gases because of the mining of uranium and other things in the process. I have no idea if that's true but just like Global Warning deniers, I'm in no position to say they are wrong.
To me, wind and sun seems like the best alternative. NIMBY would be a problem there, but not as much, because people are not scared of pollution or the thing blowing sky high