he's looked slow and tentative this year running the ball, and I can't really think of a single big play he's made in the passing game (he did drop a ball yesterday as well). And while Fitzpatrick's 1st INT was a brutal throw, I'll argue that Jackson's fumble was more costly -- the Bills were moving the ball at the time, and the fumble resulted in a 10-14 point swing.
He's been ordinary, at best, this year. Maybe it's time to feature Spiller, and see what he can do -- other than blitz pickups, I can't see how he'd be any worse.