Sticking with the run is a good plan for this game. Seattle is not going to be putting up big numbers against our defense so committing to the run and playing a time of possession game will stress an all ready poorly executing offense. Seattle does have a good run defense, but they have not been tested against a multifaceted Bills rushing attack. They probably will figure out ways to stymie the run but not before Buffalo catches them with their drawers down.
I can also see the Bills taking some shots downfield in the passing game. Clay and Goodwin could be decent contributors. This will be tough going for Tyrod because these guys can get after the passer and they don't really need to send extra blitzers. Their backfield is still pretty good too.
Going to be interesting to see how many defenders Seattle puts down in the box. If there are too many, we will see Tyrod throwing some up there. Remember, when Buffalo passes, they are also a threat to run because of Tyrod's ability to escape. Overall, this is going to be about rushing, though. Seattle's run defense is good, but Buffalo's run offense is better.
Wilson is getting healthier so this could be a game where he breaks out of the pocket and runs too. He is dangerous so the Bills will need to contain him. I really think Buffalo matches up well in this game.
I also think Buffalo's DBs will be fired up for this game. They have been playing way below their ability. I'm thinking they get back on track in this one.