We'll see how good that Carolina run defense really is when it goes up against the #1 rushing offense in the NFL. Going to be an interesting game. Tyrod will need to work the sidelines rather than the middle against this defense. With a rusty Cam, I certainly don't see an easy win for the Panthers. I think our own D is going to be pretty good this year. If Cam tries those 5-7 step drops our D could make him pay.
As for an advantage for the coach, I don't see it. Coach is just going to keep the players focused on their assignments. There won't be any last minute wrinkles added just because he knows the Panthers offense. Sure, they will game plan but it will be the same as it would for any other team.