Dealing with losses early in the season is entirely different from dealing with them later in the season.
Early on there's a greater sense of denial, more finger pointing at referees, blaming 2nd string players etc. I lived in complete denial through week 7 last year and thought that Dick Jauron had proved me wrong. I ate my words for the duration beginnign a week later when it became quite apparent that Jauron couldn't coach a tree to sit still.
When the Bills tank a game later in the season when you've lost all hope it's no big deal at all, it's business as usual.