Honorable mention:
1. Bills/Jets- needing only to run out the clock, Losman goes back scrambling and fumbles and the Jets take it for the winning score.
2. Bills/New Eng- Pats obviously short of 1st down on 4th down but ref heard saying "just give it to them" and Pats go on to score winning TD
3. Bills/Dolphins in 1970's with OJ- exciting high scoring game- Mercury Morris is picked up and thrown down and fumbles. Pre-instant replay, refs still get together and discuss it but decide it's not a fumble. Shocked and angry Bills defense allow Fins RB to go about 50 yards untouched for a TD. Game over.
4. Bills/Jags- Jags score on TD pass on last play after on prior 4th down play, all Nate Clements had to do was knock the pass down but went for the INT and missed resulting in a big 1st down reception
Unfortunately I think I could've gone on for a few more