What I'm noticing around the NFL appears to be possible side effects of limited offseason team activities, reduced practices with pads and teams not playing starters in preseason games. This affects the offenses more with the reduced reps.
There are several teams who usually have potent offenses that aren't clicking yet, like Green Bay and Jacksonville. For the Packers, it seemed the preseason loss of Jordy Nelson affected them as he was their deep threat. He's returned but not quite 100% so that's a factor but Aaron Rodgers is not as sharp and accurate as usual.
For the Jags, the prolific 2015 passing offense led by QB Blake Bortles and receivers Allen Robinson and Allen Hurns has not done much in the 1st 2 games.
Now, for the Bills, they had the issue of Sammy Watkins still recovering from his 2015 injury plus the team's decision to not play Shady McCoy in the preseason games. Tyrod also didn't play a lot in the preseason so with all of these factors, it's not a surprise the offense is not clicking. Add to this the surprisingly poor play of the offensive line, the late and supposed poor play calling and it's really not fair to say that Tyrod has regressed after only 2 games.