Not sure about Paup, but pretty sure Takeo Spikes suffered one. I don't recall if it ended his career, but people are generally not the same after repair.
For some positions, it doesn't matter as much. Those who don't have to run much or very fast can maintain careers at this point. So an OL or a pocket QB could, but not so much a WR, RB, CB, or LB, for instance. Tyrod would be screwed if he ever had one.
Dan Marino had a pretty bad one, got it repaired, and continued to play for several seasons, but with a noticeable limp. But he was never a runner.