Just downloaded a great shareware program for the Mac called Comic Life, so I thought I'd play around with it using that great Sam Adams pic from last year.
IMPACT
This is really an awesome little program that makes it incredibly easy to take your pictures and make comic books out of them. Took me about 5 minutes to make this one. Great user interface, simple to use, and for the Mac-heads out there it's tightly integrated with iPhoto and .Mac. Link to the software site is on the linked page, if you're interested.