Not sure which you're referring to, but obviously the Pennington juke was against the Jets.
The Bledsoe naked bootleg call was at home in mid season against the Pats*, in what I recall was one of the high profile "rematches" of Bledsoe against his former team. The Bills kept it close but, as I recall, needed a score in the 4th quarter to stay in it, and faced a tough 3rd or 4th down conversion. Some jackass called a naked bootleg for Bledsoe, of all people, and it was easily snuffed out. He was crushed, ball came out, and returned for a TD to seal it. !@#$ing bastards.
EDIT: ah yes, here is a great summary of the game from 2004 by David Staba from the NF Reporter. I used to love reading his pieces. Here is the URL:
http://www.niagarafallsreporter.com/billstuff20046.html