For this particular game, I think the precip and winds are going to be a big factor. Need to get the running game established early. Field position, which the Bills are near the bottom of the league at, will be important too.
From NWS
"Lake effect bands will become better developed Sunday afternoon/evening through Sunday night as lake induced equilibrium levels rise up around 10k feet and the northwest flow will support lake connections with the Georgian Bay and Lake Huron. Snow accumulations of a few inches will be possible east and southeast of Lakes Erie and Ontario, but forecast uncertainty is medium at this time as guidance continues to depict moving lake effect bands. The greatest snow amounts can be expected over the higher terrain south of Buffalo where a better upstream connection is also possible with Lake Huron and even Lake Superior"