Going into your draft, don't make the standard listing of players into tiers. Instead, decide which players you consider good enough to be your number one starter at each position, then two, three etc. So depending who's available at the bottom of the first you go from there. If there are two rb's that you feel are number one's (say S Jackson and Cadillac) then you should take them. If none or one are available, you can take the top rb and the top wr or qb if you want. This type of setup really helps in the later rounds when you are looking for those players with some potential that could have slipped down in the draft.
In a 10 team league, I'd think that you'd want to get at least one rb in the 1-2 round.