Not likely.
Buffalo is dead last against the run (181 ypg)
Carolina is ranked #8 in rushing (131 ypg)
Expect Carolina to (try to) run the ball all day long, win TOP and the game in a relatively low scoring affair. The key factor will be if Carolina can run the ball for extended drives, which they should be able to do against the Bills defense. If, and that is one mighty big IF, Buffalo can stop the run and force Delhomme to throw (4 TD, 10 INT), that may change the game IF the Bills D continues to come up with interceptions. But I would expect Carolina to continue to run the ball all day long unless the Bills are in the lead.