I was always a big fan of "seats on the aisles" until the Dallas game last year - I'm not sure that ANYONE inside of the row actually sat down.
A group showed up like 20 minutes into the game, took forever to get into their seats (DURING a play), then they sat there for like 10 minutes and all 6 of them had to go get more beers. Then 30 minutes later they were back. It was infuriating - did you come to a game to *watch the game* or to wander the hallways of the Ralph...
Still usually I'm big fan of the upper-deckers, near the rail, near the aisle
Those aren't Bills fans, they're rich folk, we don't like them!!
And should have added that I'm a big fan of corner endzone seats, tunnel side, up in the high 20s. Close to the action, a nice 3/4 perspective on the field and the jumobotron on the other side to catch plays that you can't see so well. Still, if you're a bit Xs and Os guy, nothing beat watching plays develop from the 300 level.