Of course not. Also, Knox & Kroft are not Smith & DiMarco.
You can have a 2 Tight End set on running plays as well.
Just because you run a 2 Tight End set now and then, doesn't mean that players like Diggs, Brown, Beasley or Davis are all on the sidelines.
If any of our wideouts have to sit out for one play during the entire game, I can live with that.