We moved from Seattle to Williamsburg VA, 12 years ago. We had 5 cats. When you drive across the USA with 5 cats, you can't stay in an nice hotel. No lobby, elevator etc. Mostly look for some 40+ former Holiday Inn, where you can back up to the room, in the dark, and start moving cat carriers in. We made the drive in 3.5 days. Once we got to VA., we put the cats on ice, at the vet, flew back to Seattle, picked up my wife's car, and the dog, and did it all over again.
Now, 12 years later, we still have 1 of the original 5. He's 16. They are all rescue cats. My wife's just a girl that can't say no.