In 2007 I was pretty happy with Lynch, Poz, and Edwards, and in the later rounds Dwayne Wright (who I was disappointed they releaded him) and Schouman.
Before that I would have to go all way back to 2001 with Clemments, Schobel, Henry, Jennings, and Brandon Spoon, Marques Sullivan and Dan O'Leary.
This year...I don't know if they will be available - but with a somewhat "reasonable" hope, I would love to see the Bills get
Brian Orakpo at 11 and Michael Oher at 28. I would be REALLY Happy if they got Oher at 28 and traded down from that 11 pick to get additional bodies.