Cool article based on the idea that Larry Johnson might be next in line.
The History of 2000 Yard Rushers in the NFL
Really interesting that of the 5 RB's to go for 2000+ yards, Simpson was the only one to do it in 14 games. If you take the best and worst game from the other runners, they would have finished with:
Dickerson 1852
Sanders 1817
Davis 1771
Lewis 1703
Barry Sanders was incredible. He started the 1997 season with 53 yards rushing after the first two games.