I tried to get about as much as I could out of every Bills game I went to. I'd show up early, drink heavily, partake in tailgating, throw the football, scream the Shout song, get into the chants of the crowd, etc, etc, etc....but I find it pretty damn annoying when some jackass is always standing up at every friggin opportunity too.
As much as I want to get into the passion of the day, I also want to see the game. Being 6'2", I'm usually not at a disadvantage anyway, but what I hate is when my eyes are glued to a particular play, and then right before it's completed the guy in front of me jumps up. Did he catch it? Was it picked? WTF happened??? That gets pretty annoying....
Standing up and going nuts is great, but continually blocking the guy behind you from seeing the action is pretty rude, IMO.