Prayers for you both. This reminds me very quickly how unimportant football is.
As for the trials, that is one of the largest benefits of going to a major university. You can get excellent care based on NCCN guidelines with 'most' oncologists in the country (understanding there is good and bad everywhere as far as docs go). They are, however, limited to 'approved' treatments in most cases and most follow NCCN guidelines for treatment. These guidelines, in theory, keep treatment fairly standardized and based on well accepted studies/outcomes etc.
Getting on the 'new' trials, however, usually takes you visiting one of these big centers. It sounds as if your wife has gone through the 'guideline' treatments and her oncologist is recommending you seek a trial. Some regional/community hospitals enroll patients in trials that are centered at major universities. Hence, your travel for treatment etc may not be as extensive as you think. If your oncologist has recommended a trial/hospital...it sounds like that's a good next step.
Tell your wife there's a lot of people rooting for her!