The days of stadium concerts are over. Performers prefer venues of 20K or less. Even in its heyday the Ralph/Rich didn't host that many concerts- the last one there was in 2001.
To all those saying you need a dome, exactly what other uses are you going to get out of it?
Concerts, monster trucks, wrestling? Any of these held at a dome would just take away from business for First Niagara Center.
Super Bowl? An extreme long shot.
Conventions? Maybe, but once again it would take away business from an existing venue. Although I've read that the convention center is undersized, would a stadium floor attract that many more conventions? I have my doubts.
Final Four/ NCAA regionals? Possible. Not going to rule it out, but attracting the Final Four would be almost as much a long shot as getting a Super Bowl. Plus, the FNC already gets NCAA subregionals semi-regularly.
UB football? UB seems unconcerned about upgrading its program, and would prefer to keep playing in its bare-bones stadium on campus.
I'd like to see a new stadium that can be used more than 8-10 times a year, but I'm having a hard time seeing other uses for it. Any stadium that is going to see use outside of Bills games needs to be in an urban center, either downtown Buffalo or Niagara Falls. Orchard Park just doesn't cut it.