This reminds me of how teams schemed against Peyton Manning at his height. I agree, time of possession will help. Surprisingly this has been a weakness for the Bills the last few years, but seems to be an area of strength this year (hopefully because of an improved running game).
I personally think, that the key to the game will be the Bills getting the lead. It's pretty obvious from the last few years, that our nickel defense is better when they have the lead (13 seconds notwithstanding). Lost in all the Dolphins talk, is the fact the while Tyreek and Tua are great, they have had solid, but not otherworldly numbers this year. The Dolphins running game is what blew that 70 point game wide open.
We get a lead, eat some clock and make Tua pass into our nickel defense I like our chances. Easier said than done ! Here's praying to a quick start.