He's difficult to defend. If you get to him quick on a blitz, fine. Once he breaks containment odds are in his favor.
20-1 vs NFC teams in his career. Obviously, seeing him once every 4 years is a part of that. AFC teams see him more often, so they have a decent idea of how to defend him.
To me, the main MVP candidates are Lamar, McCaffrey, JA, Mahomes, & Myles Garrett. Remove these guys from their teams and they're .500 ish.