I suggest you take a look at the tape. This is where stats are very deceiving. The 1st int wasn't Pickett's fault. Yes, the 2nd one is on him as he threw inaccurately as he was backing up. The 3rd one was a hail mary.
In short, in the sample of a half Pickett showed a lot of promise. He was willing to " rip it" and " wing it" unlike Mitch. He also ran in 2 tds which was impressive.
This is a very tough ask for Pickett. Making his first NFL start in Buffalo vs a very good defense. Buffalo's track record vs rookie Qbs is very good too. The Steelers oline is very good and Harris is not a game breaker. He's more of a smasher and a grinder. The Bills run D should play well. I think we will see a Steeler offense that will throw it a little bit more downfield. Take chances because truthfully they have nothing to lose.
Conversely, I think the Bills try to establish the run and feed Singletary. Take some shots down field with Diggs. Shakir should have a few more opportunities as well. It's key the Bills offense comes out sharp and doesn't turn over the ball. In the past, Tomlin has had great game plans against Allen. However, with no Watt and a banged up secondary makes the Steelers more vulnerable and beatable.
Steelers will show up, be ready, excited about Pickett. The Bills are at home with the superior team.
Bills 31
Pitt 20