Bend but don’t break would be my plan. I’d key on kelce in the red zone and put Tre on Tyreek. About the only time you can even think of single coverage is around the red zone. I’d be worried about crossing routes with him there but that’s about the only route that would scare me.
Try to get Mahomes off those two guys and let his third and fourth options try to score the tds. Easier said than done. I’m no coach so what do I know.