They're DLine is under-powered and with Harrison gone and Woodley a shell of himself, they get minimal pressure off the edges.
That being said, Dick LeBeau is the greatest Defensive coach I have ever had the pleasure to watch and he has a significant history of completely destroying rookie QB's.
I expect to see a LOT of Stillers in the box and a healthy measure of zonedawgs designed to bring interior pressure. The problem that creates is that Ike Taylor is really the only quality cover guy they have and he might be watching in civvies on Sunday. If the Bills have plenty of maxprotect in the gameplan, they might be able to take advantage of that issue; otoh a bunch of injured receivers is not part of the formula to do that.
This is going to be a really intriguing matchup.
P.S. Nice call last week on the matchup with the KC offense. I was afraid they were going to hold the ball for 35-40 minutes by attacking us with a horizontal gameplan heavy on TE's and RB's, but they were never able to get anything going. That was some good, quality entertainment.