I think the big difference is that the Jags had been there for a full week already, had a game, got completely used to the surroundings, routine and time zone. I know people think this is just sour grapes on the Bills part but that had to be an advantage, I don't see how it couldn't have been.
To be honest if we had simply lost that game I really wouldn't be too bothered about it, just because of how out of the ordinary it was. The killer is the injuries that occurred.