Yes a shifty runner will not have success in a Man/Power Scheme. That is why McCoy did so poorly under Roman...Oh wait, never mind.?
As you can see from this post it had a strong effect on the Oline. The only thing that effected McCoy was the fact that his Oline didnt fit the Scheme.
As a matter of fact Arian Foster was a one cut and go RB pretty much and played most of his career in a zone scheme.