Gonna try to give some players that I haven't really seen mentioned for the Bills but I think make sense (which means avoiding QBs because Buffalo has been matched with all of them by now lol). I'm also going to skip the O-Line because I just don't know very much about them.
12: Roquon Smith/Tremaine Edmunds - I think it has to be a QB or LB here and these are the two LBs worth taking at 12.
22: DJ Moore - I think DJ Moore is the best WR in the draft class, a Stefon Diggs-esq WR. He's incredibly explosive after the catch and could wreak havoc in the Daboll system.
53: Nathan Shepherd - He's a very raw prospect, but he has all the makings of a great DT and I think Kyle Williams could be a good mentor for him/placeholder until Shepherd is ready to shine
56: Carlton Davis - He has the height and length that McDermott looks for in his corners. This is an awesome corner class and it would make a lot of sense to add one with Vontae's health.
65: Nick Chubb - He proved at the combine that his explosiveness has returned after his awful injury, and he's a beast of a runner.
Day 3 guys:
Genard Avery - An absolute freak athlete of a linebacker; I think he's likely a Sam at the next level.
Nyheim Hines/Martez Carter - I group these two together because they're the same kind of prospect: big play threats out of the backfield that can also return kicks.
Isaac Yiadom - Another corner with the length that McDermott likes
J'Mon Moore - A tall vertical threat that was on the receiving end of a lot of Drew Lock's TDs this season.