The biggest challenge that Pitt can give Allen is the ability to get home with the pass rush while clogging his escape lanes AND holding plastered man coverage so there's no one to throw to and no where to escape to.
If Joe Haden is out that will be a huge boast, but the Bills need to come up with a better blitz bearer than the smoke screen. I mean, its great when it works, but you can only go to the well so many times. We need to get better at slip screens to the RB and quick slants to beat it.
At the same time, I feel a lot better about the Bills OLine with Mongo at RG than with Winters. This will be a very interesting game.