Your last sentence is the key I thInk.
Need all all players playing at top efficiency.
How often have have we seen a team with home field, everything wrapped up, rest starters and lose their first playoff game.?
i think we want to keep the core sharp. Pending minor injury, bad field conditiOne, I'd play starters 1-2 quarters to keep them sharp, then put in backups.
Yes, it's an injury risk. But getting stale is also a risk.