I'm not going to predict scores, but I'll predict wins and losses:
Week 1 - Jets at Bills - WIN
Week 2 - Bills at Dolphins - WIN
Week 3 - Rams at Bills - WIN
Week 4 - Bills at Raiders - LOSS
Week 5 - Bills at Titans - WIN
Week 6 - Chiefs at Bills - WIN
Week 7 - Bills at Jets - WIN
Week 8 - Patriots at Bills - WIN
Week 9 - Seahawks at Bills - LOSS
Week 10 - Bills at Cardinals - WIN
Week 11 - BYE
Week 12 - Chargers at Bills - WIN
Week 13 - Bills at 49ers - LOSS
Week 14 - Steelers at Bills - WIN
Week 15 - Bills at Broncos - WIN
Week 16 - Bills at Patriots - LOSS
Week 17 - Dolphins at Bills - LOSS
Bills finish 11-5 and win the division. I think week 17 might be a "we rested our starters" loss. I think the big win of the season is vs the Chiefs, and I give the Bills the edge because they are playing at home and will come in treating it like a playoff game and will surprise the Chiefs with their physicality.
i also think the defensive line is going to really good this year, generating lots of pressure on QB's.