My personal keys to the game:
Bills:
Have to stop Dion Lewis. He's killed us in the past with NE.
Contain Mariota to the pocket, especially on 3rd down
Get McCoy going early and often.
Daboll needs to show he's capable.
This Titan team has been talked about quite a bit this week in the media. They are solid. I do think them missing 2 key players on defense will help.