The Reagan quote kind of became obsolete by 1992. Is there some other wall that needs tearing down? Sure, it's historical, but that's the thing. "Ask not...." is something that stands the test of time and is a central tenet of what made/makes this country great --- to wit, that America was founded on sacrifice for the benefit of the whole rather than the 'where's mine?' mentality (which, sadly, has taken a choke hold in the last 15 years). The JFK era is on the cusp of not really mattering who was in what party b/c it's so far removed from today's context. If someone put a gun to my head and asked which party Truman, Eisenhower, etc. belonged to, I'd have a 50% chance of living.... party doesn't matter. What they did mattered, what they said mattered. Some presidents' most famous quotes stuck to the there and then, some aimed higher. Without a doubt 'Ask not...' is remembered more, and deserves to be remembered more than the other piddler quotes proposed. "I did not have sex..." will not be remembered 100 years from now; it won't matter 100 years from now. But JFK's line will still be a truth; he had a great speechwriter.