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The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
It's sad what they are doing to older people. Complete tyranny. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Could the virus lay dormant? Or still multiplying in a person not over yet. A couple reasons. Or a dead virus. But my thinking if this virus could lay dormant? But in a less infectious way to others? Not sure on the person self health? Lots of virus can do this, lay dormant. Some question's hopefully future answers them. Different topic looks like bad news for Iran daily cases picking back up. That's really good Magox. Going down is really good. Hope goes and stay that way. -
The Big Gamble: Hydroxychloroquine
Buffalo Bills Fan replied to Magox's topic in Politics, Polls, and Pundits
Well they are real doctors Tibs. lol -
The Big Gamble: Hydroxychloroquine
Buffalo Bills Fan replied to Magox's topic in Politics, Polls, and Pundits
Honestly Tibs, those don't support Trump hell some youtube doctors. Work on the field said HCQ and Zinc works really well. If I ever get this virus, I want those two early. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Feel bad for some members here on twobillsdrive have covid19. Wish them the best. Have to support our fellow members here. Ya agree with President Trump. -
Oh my sorry for you're mother. Keeping everyone in my thoughts and prayers.
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The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Right . That's super wrong putting infected people in nursing homes . He is on Nancy Pelosi level for me now. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
This makes me little angry -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Ya feel for them -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
https://www.nbcnews.com/health/health-news/cdc-issues-alert-doctors-rare-covid-19-mystery-illness-kids-n1207081 CDC issues alert to doctors on rare COVID-19 'mystery illness' in kids The illness was given an official name: MIS-C, or multisystem inflammatory syndrome in children. May 14, 2020, 6:31 PM EDT By Erika Edwards The Centers for Disease Control and Prevention issued a health alert to physicians Thursday on what has emerged as a rare but potentially deadly condition linked to COVID-19 in children. The illness, which the CDC calls "multisystem inflammatory syndrome in children," or MIS-C, has been reported in at least 19 states and Washington, D.C. It was previously referred to as pediatric multisystem inflammatory syndrome. Full coverage of the coronavirus outbreak At least 110 cases have been reported in New York, and three young people — ages 5, 7 and 18 — have died. New Jersey has at least 17 cases, and California has six. Other states, such as Connecticut, Georgia, Kentucky, Ohio and Washington, have reported small numbers of cases. Kids ‘do need to be protected’ from coronavirus, doctor says MAY 14, 202002:41 The CDC's health alert provides guidance for diagnosis of MIS-C. The diagnostic criteria include a fever of at least 100.4 degrees for at least 24 hours, evidence of inflammation in the body and hospitalization with problems in at least two organs (such as the heart, the kidneys or the lungs). -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
To the Editor, The 2019 novel coronavirus (2019-nCoV, COVID-19) has spread in nearly 100 countries, infected 217,645 patients, and resulted in 8942 deaths worldwide. The major clinical feature is Respiratory Distress Syndrome and one key complication is Acute Cardiac Injury [1]. Interestingly, a recent article of IJC may provide a clue to heart protection for COVID-19-infected individuals, based on the oxidative stress theory [2]. According to recent clinical reports, the therapeutic time for COVID-19 infection is much longer than 14 days, but long-time viral stimulation is prone to suddenly elicit intensive immunological reactions, cytokine storm and immune-cell infiltration in vivo; however, some immunocytes especially macrophages and neutrophils can produce numerous reactive oxygen species (ROS) including H2O2, (·O2 −), (·OH), etc. [[2], [3], [4]]. Generally, a certain level of ROS is important for regulating immunological responses and for clearing viruses, but excessive ROS will oxidize cellular proteins and membrane lipids and quickly destroy not only virus-infected cells but also normal cells in lung and even heart, resulting in multiple organ failure. Thus, a potential anti-oxidative therapy could be proposed to alleviate cardiogenic casualties caused by COVID-19. Inexpensive medicinal antioxidants include Vitamin C (ascorbic acid) and Vitamin E, because their reductive hydrogen atoms can react with ROS and then produce nontoxic water [5]. Plant-derived molecules (similar to ancient Chinese medicine), such as Curcumin and Baicalin, may have potential anti-oxidative efficacy, too. Predictably, a proper dose of antioxidants may ameliorate cardiac injuries of critically ill COVID-19-infected patients (but possibly not including mild-symptom patients). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133895/ Oxidative stress might be pretty big. What are the main causes of oxidative stress? Factors that may increase a person's risk of long-term oxidative stress include: obesity. diets high in fat, sugar, and processed foods. exposure to radiation. smoking cigarettes or other tobacco products. alcohol consumption. certain medications. pollution. exposure to pesticides or industrial chemicals. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
KENTUCKY Published 21 hours ago Family of Kentucky EMT shot by police executing search warrant files lawsuit By Barnini Chakraborty | Fox News Facebook Twitter Flipboard Comments Print Email Fox News Flash top headlines for May 13 Fox News Flash top headlines are here. Check out what's clicking on Foxnews.com. The family of an EMT who was asleep in her Kentucky apartment when police executed a search warrant the family claims was at the wrong address has filed a lawsuit accusing officers of firing more than 20 shots into Breonna Taylor's home. The 26-year-old aspiring nurse was killed on March 13 after being shot eight times by Louisville police officers. Her mother, Tamika Palmer, said she filed the lawsuit to get justice for her daughter. AHMAUD ARBERY'S MOTHER SAYS GEORGIA OFFICIALS WOULD HAVE 'COVERED UP' SON'S MURDER "I want them to say her name," she told The Washington Post. "There's no reason Breonna should be dead at all." The lawsuit, filed late last month, accuses the officers of wrongful death, excessive force and gross negligence. https://www.foxnews.com/us/family-of-emt-shot-by-police-files-lawsuit https://www.foxbusiness.com/lifestyle/mcdonalds-workers-shot-coronavirus-closure McDonald's workers shot over coronavirus closure: Police 3 employees injured in shooting over closure of dining room Facebook Twitter Comments Print Email Associated Press Coronavirus social distancing inside McDonald's restaurants 'can be managed': Ed Rensi Fat Brands chairman and former McDonald's USA CEO Ed Rensi on reopening resturaunts while coronavirus carries on. OKLAHOMA CITY — Two McDonald's employees in Oklahoma City were shot and wounded by a customer who was angry that the restaurant's dining area was closed because of the coronavirus pandemic, police said. TickerSecurityLastChangeChange % MCDMCDONALD'S CORP.171.79-1.03-0.60% A female suspect was in custody after the Wednesday night shooting, but police have not yet released her name or what charges she may face. The woman entered the lobby of a McDonald's in Oklahoma City and was told the dining room was closed for safety reasons, police said. CORONAVIRUS LEADS HOSPITALITY BRANDS TO RELEASE SECRET RECIPES AMID QUARANTINES The woman "became agitated and fired two to three rounds at employees,” Oklahoma City Police Capt. Ronnie Beck said. Lots of horror stories people out there. Lots of police acting terrible, Mcdonalds story people out there getting crazy. Protesters like President Trump said one day treated rough. Feel for them. People in this world need to use there head (not to you or board members) -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Ya I am still am. Just hate when people over abuse there powers on people. No reason for any of it. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
My uncle telling me earlier police abusing there power sadly. Saw some thing's online it is bad. Shooting people when sleeping. Or wake up to it. Don't support any of that. Hate it people go thru that. That's getting bad. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
https://covid19tracker.health.ny.gov/views/NYS-COVID19-Tracker/NYSDOHCOVID-19Tracker-DailyTracker?%3Aembed=yes&%3Atoolbar=no&%3Atabs=n This site is really good to check out. So much details to it. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Yes it is Magox. Very good. (My last post they updated NY). But anyway's let's hope this trend continues down. -
Agree
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The Media's Portrayal of Trump and His Presidency
Buffalo Bills Fan replied to Nanker's topic in Politics, Polls, and Pundits
Wow . Don't wish that upon anyone. Awful that guy said ( not Trump Jr). Wouldn't wish that on anyone. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
USA Total 1,381,963 +14,325 81,568 +781 1,040,115 4,175 246 9,705,424 29,321 New York 345,987 +581 26,874 +62 260,750 17,785 1,381 1,204,650 61,924 [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [projections] New Jersey 140,930 +922 9,312 +48 130,083 15,867 1,048 425,933 47,954 [view by county] [1] [projections] Illinois 79,007 +1,266 3,459 +53 74,903 6,235 273 442,425 34,914 [1] [2] [3] [4] [projections https://www.worldometers.info/coronavirus/country/us/ Good sign to come following days for NY? Unsure if accurate. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Right. Thanks man. See thinking after she went thru might be 1 in a million or so chances for surviving for anyone. But happy and good for miracle's happen. Being so close to death esp turning blue hands and feet. And at the hospital my sister and husband say good bye few weeks ago. But she survived with low ecmo percent. Ya the coxsackie B I think almost got the sudden death (think it was that bad one). But she's tough made it thru and been home I think past couple- few weeks. Witch is great news. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Just wanted to post an update on my daughter Cassandra. First, she is doing fantastic. She is doing her school work, playing, and enjoying spending time with her family. It has been a week since we left Buffalo Children's Hospital. I want to thank all of you for the cards, kind words, and prayers. Many people have asked me what exactly happened so I will explain. I needed to collect my thoughts before I posted just because there is so much information. Cassandra was diagnosed with myocarditis which is the inflammation of the heart. Only 1 out of 100,000 children have this happen and usually one of the causes is a virus. Cassandra happened to be the unlucky winner. The virus she contracted was called Coxsackie B3. This virus is a common childhood illness. Most young children have mild or no symptoms. Very few children are extremely sick and in Cassandra's case, she was literally struck by lightning being child 100,000. Overall, this condition is very rare for a common virus. The day we took Cassandra to WCA ER in Jamestown is a day I will never forget. In the morning, Cassandra had a slight fever and seemed to be calm. The only alert I had was she pointed to her right side and stated that it hurt. Something in me and alerted that perhaps she might have appendicitis and we rushed her to the emergency room. About ten minutes after she was admitted, Cassandra started to deteriorate while I and the health care professionals were watching. Immediately Buffalo Children's was called and a chopper flew in to stabilize her and send her out. Her hands and feet were getting cold and she was turning pale and blue. I couldn't believe what I was witnessing and that my child was dying in front of me. I also witnessed so much more which is too hard to explain at this time. As Cassandra was being flown to Buffalo Children's Hospital, my husband and I drove. As we approached the city, the hospital contacted us by phone and asked for my consent to put her on life support. I told them to proceed but wasn't sure if she was going to make it. It was a critical time but we both had to stay focus to make it to where she was at. As we entered Buffalo Children's, both my husband and I were allowed to enter together just because security made an exception (COVID regulations) just in case she died and we were both there to say our goodbyes. As hours passed, Cassandra was stabilized on ECMO life support. A kind doctor at Children's that night sat with my husband and I and stated we saved her life and that if we even waited an hour later, she would not be with us and if we would have rushed her to the hospital earlier, she may have been misdiagnosed and sent home. He mentioned the timing was perfect. Cassandra's chances of surviving were less than 40% when she had to be put on life support (ECMO). In other words, miracles do happen and prayers are answered. It was a mere coincidence that Cassandra suffered this Coxsackie B virus during a COVID pandemic. As I am writing this, the best advice I could provide you is be careful. Careful I mean is wash your hands, cover your face, and respect distance. I am seeing people out there not doing this. What I learned from all of this is no one is an exception from getting any virus and it destroying them. It doesn't matter if your healthy or not. My daughter was extremely healthy before getting sick. My sister posted few days ago. Glad doing well. Don't use facebook much. Coxsackie B virus Share Coxsackie B4 virus. Coxsackie B (also written coxsackievirus B) is a group of six types of enterovirus belonging to the Picornaviridae family. They cause symptoms ranging from gastrointestinal distress to aseptic meningitis, pericarditis and myocarditis. Like other enteroviruses, Coxsackie B viruses have a tropism for muscle cells and have been linked to myalgic encephalomyelitis and chronic fatigue syndrome, fibromyalgia,[1] as well as Type 1 Diabetes. Contents [hide] 1Symptoms 2Types 2.1Coxsackie B1 2.2Coxsackie B2 2.3Coxsackie B3 2.4Coxsackie B4 2.5Coxsackie B5 2.6Coxcackie B6 3Immune system 4Mitochondria 5Exercise 6Chronic infection 7In human disease 7.1Myalgic Encephalomyelitis 7.1.1Blood testing 7.1.2PCR 7.1.3Muscle biopsy 7.2Fibromyalgia 7.3Type 1 diabetes 8Testing 9Antivirals and immunomodulators for coxsackievirus B 10Factors which worsen coxsackievirus B infection 11See also 12References Symptoms[edit | edit source] Symptoms of infection with viruses in the Coxsackie B grouping include fever, headache, sore throat, gastrointestinal distress, extreme fatigue as well as chest and muscle pain. It can also lead to spasms in arms and legs. Types[edit | edit source] Coxsackie B1[edit | edit source] Coxsackie B2[edit | edit source] Coxsackie B3[edit | edit source] Coxsackie B3 is found in 20-25% of patients with cardiomyopathy and myocarditis.[2][3][4][5] Coxsackie B4[edit | edit source] Coxsackievirus B4 has a cell tropism for natural killer cells and pancreatic islet cells.[citation needed] Coxsackie B5[edit | edit source] Coxcackie B6[edit | edit source] Immune system[edit | edit source] In a mouse model of myocarditis, Coxsackievirus infection was found to upregulate Toll-like receptor 4 on mast cells and macrophages immediately following infection. It also increased numbers of mast cells.[6] The induction of interferon signaling and the induction of apoptosis are required for normal control of a Coxsackie B3 infection. Coxsackievirus B3 cleaves Mitochondrial Antiviral Signaling (MAVS) protein and Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta TRIF to inhibit type I interferon induction and evade host immunity.[7] Conversely, upregulation of MAVS inhibits Coxsackie B3 by increasing type-1 interferon production.[8] Mitochondria[edit | edit source] Coxsackievirus B3 cleaves Mitochondrial Antiviral Signaling (MAVS) protein to inhibit type I interferon induction.[9] Conversely, upregulation of MAVS inhibits coxsackie B3 by increasing type-1 interferon production.[10] Exercise[edit | edit source] Several studies of a mouse model of Coxsackie B3 myocarditis have found that exercise increases the virulence of the infection and results in poorer outcomes.[11][12][13][14][15] These studies compare two groups of mice, both infected with CVB3, one that is exercised and the other, sedentary. They found: Exercised mice died of congestive heart failure (the majority while swimming) and had 530X the amount of virus.[14] Exercised mice had increased viral titers, mortality and fiber necrosis.[12] Exercised mice had higher viremia and virus in the hearts and no circulating interferon; non-exercised mice had detectable interferon activity, higher levels of neutralizing antibodies[15] Exercised mice died at much higher rates (52% v. 0 sedentary mice), but not if they were immunosuppressed.[11] Increased T cytotoxic, T suppressor, and T cytotoxic, suppressor/T helper cell ratio, and myocardial inflammatory and necrotic lesions with exercise at 48 hours after infection. "Failure to restrict physical activity in the acute phase of this infection may well contribute to the progression of the disease."[13] Chronic infection[edit | edit source] Main article: Non-cytolytic enterovirus Coxsackievirus B is able to establish a chronic intracellular non-cytolytic infection which can persist for years. Non-cytolytic enterovirus infection does not involve the destruction of infected cells. Non-cytolytic infection is difficult to measure in the serum as viral particles remain in the cell walls of tissues. The molecular mechanisms of non-cytolytic infection were examined in a small study comparing Coxsackie B2 virus cultured in vitro to RNA extracted via muscle biopsy from eight patients with a chronic fatigue syndrome diagnosis. All patients had symptoms of muscle fatiguability. Four of these samples tested positive for enteroviral RNA. In all four patients with enteroviral-specific RNA, the enteroviral RNA had equal amounts of positive sense and negative sense RNA. By contrast, CVB2 virus in culture produced positive sense RNA at a ratio of 100:1. An equal ratio of positive to negative sense RNA would inhibit the translation of virus-specific gene products, explaining the failure to attract a response from the host immune system, and my account for how CVB2 could establish a persistent infection in these four patients.[16] Models of persistent infection of the heart[17] and brain[18] have also been studied in mice and in thyroid carcinoma. In human disease[edit | edit source] Viruses in the Coxsackie B family progress to myocarditis or pericarditis, which can result in permanent heart damage or death. Coxsackie B virus infection may also induce aseptic meningitis. As a group, they are the most common cause of unexpected sudden death, and may account for up to 50% of such cases.[19] https://www.me-pedia.org/wiki/Coxsackie_B_virus Coxsackie virus is crazy. See sudden death lots of people . If people think if a virus cannot attack the heart or place there think again. Or any place in human that a certain virus attacks. -
The Next Pandemic: SARS-CoV-2/COVID-19
Buffalo Bills Fan replied to Hedge's topic in Politics, Polls, and Pundits
Living in fear can be bad on immune system. I'm taking this virus complex and something new to learn each time.