The Bills are probably talented enough that they can do whatever they want and it probably won't really matter. Josh Allen gives them this ability, but a rb is just not good draft value.
Breece looks like he should be a good player, I'm just not seeing anything that special to be an exception to the rule in today's NFL. He seemed to be slipping into the 2nd round, before he kept getting rumored to the Bills at 25. That looks more like his agent trying to get someone to take him before the Bills pick.