Only if they think he's a starting CB in the NFL. The Bills are in salary cap jail for the next few years, early picks should be WR, DLine, OT, CB. If he's the best player left on their board and they think he'll translate to CB in the NFL it wouldn't be my first choice but I wouldn't hate it. Safeties are cheap enough in FA that even though it's a big need, I'd be disappointed with a Safety in round 1.