Let's play a little game. You're the coach and you come up with the game plan. What do you do?
Here's what I'd do. On defense, I would blitz every single snap for the first 4 or 5 drives. While blitzing doesn't slow Brady down (usually), I think if you were to Blitz him on every down this would eventually throw off his game. If the blitzing continues to work, stick with it. If not, do a 3 man rush and drop everyone else in coverage.
On offense, I would game plan to throw dump off passes for 5 yards all game long. Create short gains that wear down the clock and make long extended drives for the bills. If we score, onside kick on every kick off. Yes, every kick off. That sounds ridiculous, but at some point you're going to baffle the Pats and throw them off.
I cannot see any scenario where we win this game playing the way the bills have played in these 12 weeks. I know that none of what I mentioned will happen. I'm just a fan that has watched the Patriots obliterate the bills the last 17 years