The bad publicity isn't what's going to hurt Roseanne.
This cancellation doesn't just affect Roseanne Barr. It affects John Goodman and all the other actors. More importantly it affects the writers, show runners, sound people, makeup, and all the faceless crew behind the camera.
The off camera talent is what makes a good show run. And the next time they're weighing their options, are they really going to want to work with the kind of on camera talent that could end your show with a single Tweet or boneheaded quote on some talk show?
Look at Charlie Sheen. How's his career been since Two and Half Men? Nobody wants to work with him