I know it's pointless to mention individual gripes about Madden, but I really wish there were a way to simulate the rest of the game from a given point. I really hate it when I'm playing in franchise mode and I'm up by like 40 pts. and I still have to sit there and play the game out.
On topic though I'll pick up Madden 06. I've gotten practically every one since 92, so I don't see any reason to stop now. Some might call me foolish, but I actually do the hell out of each year's version.