"Reggie Bush Sweepstakes" - he was supposed to be the next Gale Sayers and was a shoo-in to be the #1 pick. The people of Houston also wanted Vince Young, after that amazing NCG, and because he's from Houston:
http://sportsagentblog.com/2006/04/28/what-went-wrong-in-the-reggie-bush-sweepstakes/
And, how about right on Casserly's wikipedia page:
Mario Williams, who many criticized for being the #1 overall pick in 2006 (behind college standouts Reggie Bush and Vince Young), made the Pro Bowl in the 2008 season.
I don't listen to Jim Rome anymore, but I did at the time, and the whole theme of the show the next day, and probably more days, was what a clownass pick it was, complete with emails from Sam Bouie saying "Great pick."