Interestingly, James is ranked 12th in the league [71attmpts / 277totyds / 3.9avg / 69.2ypg] which places him one spot above Lynch who is at 13th in league [79attmpts / 275totyds / 3.5avg / 68.8ypg].
Arizona as a team, however, is ranked 25th [108 attempts / 348 total yards / 3.2avg / 87.0ypg]
while Buffalo is ranked 20th [116attmpt / 408 totyds / 3.5avg / 102.0ypg]
Apparently, Jackson is the difference maker as he ranks 42nd in the league and the Cards don't have a backup RB in the top 50. So, as a team, the Bills have an edge (no pun intended) in running; however, the Edge is marginally outproducing the Beast. Lynch does have 4 touchdowns to James' 2.
Conclusion, I really think they try to establish a running game tomorrow. Hopefully, we're ready and can make them one dimensional.