Of course! The more complex and nuanced the rules, the more gray area. The more gray area, the more there is to look at, be distracted by, or miss. And as you say it leads to total inconsistency from play to play, game to game, and crew to crew.
One interesting aspect to all this that was mentioned up thread: with a dedicated full time officiating crew, it will become much easier to fix games through bribing a handful of individuals who arguably would have more reason to accept bribes.
The 58 year old judge who refs for fun on the weekends probably isn't looking for bribe money.
The full time "professional ref" who makes X per year would.
This sort of thing has happened in big time sporting leagues all over the world.
People are naive to think it can't happen in the NFL.