For those of us with Houston connections, KHOU-TV in Houston is now calling Galveston Bay as ground zero, it's no longer looking like it's going to directly nail Matagorda Bay.
As you probably know, that's not good for SE Houston - the surge will absolutely hammer Channelview and IMO up to and including Humble. It's not looking good at all.
Here are a couple of links to KHOU-TV I've been using to follow the developments in and around Houston:
5AM forecast - Galveston Bay (Houston) is ground zero
KHOU-TV Blog (misc updates posted as soon as they come in)
KHOU-TV's live web feed - great coverage for those of us who have Houston connections
Hopefully the people to whom you are connected are on the road now. My father and mother-in-law (as well as his mother) are making their way to Lufkin. They were unable to find a room anywhere closer than Dallas, so they're going to stay at a shelter, which I know they won't like but given the alternative...
My sister-in-law and her husband are leaving this afternoon to go stay with his family in San Antonio, farther from home than my mother and father-in-law are willing to travel. My brother-in-law is choosing to ride it out in his big 'ol brick house in western Houston (I've forgotten the neighborhood's name), but wife's dad doesn't think that will be too safe - especially given the current health of his mother.
I'd rather see my brother-in-law go, but he's convinvced he'll be OK since he's not in the mandatory evac zone. There's no arguing with him, but at least I now know my wife isn't the only bullheaded member of the family. I just pray he, his wife, and their daughter (she's 17) get through it.
This storm isn't going to be fun for a lot of people.