Nix left Buffalo with John Butler and A. J. Smith after the 2000 season. He was initially the Director of Pro Player Personnel (2000–2001), but after Butler died, Smith was promoted to General Manager, and Nix to Assistant General Manager.
Nix's job with the San Diego Chargers was to oversee both professional and college scouting and to be one of the main decision makers in each NFL Draft. Nix was a major reason the Chargers turned around from a losing football team to a rebuilt, winning team. In 2004, three players Nix drafted were selected to the 2005 Pro Bowl. In 2005, six players Nix drafted were selected to the 2006 Pro Bowl. In 2006, eleven players Nix drafted were selected to the 2007 Pro Bowl. In 2007, eight players Nix drafted were selected to the 2008 Pro Bowl.
The Chargers won four out of the last five AFC West titles with Nix as Assistant GM and Director of Player Personnel, in charge of college scouting and instrumental to the decision making process of their NFL drafts. http://en.wikipedia.org/wiki/Buddy_Nix