To get back to the OP, one would think that it would be impossible for us to screw this one up with the level of talent in this year's draft (and who knows who will declare in the next few weeks).
That being said, I'd go with the best OT available at this point. Hell, maybe spend our 2nd rounder on a top OT prospect as well depending who's available. I strongly believe that the Bills are going to look to FA or a trade in order to bring in a QB.